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A bioactive sphingolipid potentiates LPS-induced production of inflammatory cytokines decreases the mitochondrial membrane potential and induces cell death in mouse astrocytes induces demyelination of mouse cerebellar slices at 0.1 and 1 UM inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes inhibits PPARa-mediated gene transcription in C6 glial cells at 10 and 15 UM levels are increased in postmortem brain from patients with Krabbe disease
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